AKOS BRN-0722 - Names and Identifiers
Name | 4-Bromo-2,5-dimethylphenylboronic acid
|
Synonyms | AKOS BRN-0722 2-Borono-5-bromo-p-xylene 4-Bromo-2,5-Dimethylphenylboro 4-Bromo-2,5-dimethylphenylboronic acid 4-BROMO-2,5-DIMETHYLPHENYLBORONIC ACID 4-Bromo-2,5-dimethylbenzeneboronic acid (4-Bromo-2,5-dimethyphenyl)boronic acid Boronic acid, B-(4-bromo-2,5-dimethylphenyl)-
|
CAS | 130870-00-7
|
InChI | InChI=1/C8H10BBrO2/c1-5-4-8(10)6(2)3-7(5)9(11)12/h3-4,11-12H,1-2H3 |
AKOS BRN-0722 - Physico-chemical Properties
Molecular Formula | C8H10BBrO2
|
Molar Mass | 228.88 |
Density | 1.50±0.1 g/cm3(Predicted) |
Melting Point | 194-202℃ |
Boling Point | 350.3±52.0 °C(Predicted) |
Flash Point | 165.6°C |
Vapor Presure | 1.66E-05mmHg at 25°C |
pKa | 8.44±0.58(Predicted) |
Storage Condition | Inert atmosphere,2-8°C |
Refractive Index | 1.574 |
Physical and Chemical Properties | Storage Conditions: Keep Cold |
AKOS BRN-0722 - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Hazard Class | IRRITANT, KEEP COLD |
AKOS BRN-0722 - Introduction
4-Bromo-2, 5-dimethylbenzeneboronic acid is an organic compound with the chemical formula C9H11BrBO2. The following is a description of its nature, use, formulation and safety information:
Nature:
1. Appearance: 4-bromo -2,5-dimethylphenylboronic acid is white to light yellow crystalline or solid.
2. relative density: 1.44g/cm³.
3. melting point: about 235-236 ℃.
Use:
1. As an important intermediate in organic synthesis, it can be used to synthesize a series of compounds with biological activity.
2. In organic synthesis, it can play an important role as a catalyst or ligand.
Preparation Method:
The preparation method of 4-bromo-2, 5-dimethylphenylboronic acid can generally be achieved by the following steps:
1. react 2,5-dimethylphenylmagnesium bromide (2, bromide) with triphenylphosphine dichloromethanesulfonate (chloromethyl phenyl sulfonyl triphenylphosphine) to generate tetraphenylbromobenzene boronic acid intermediate.
2. The intermediate is reacted with hydrochloric acid to generate 4-bromo-2, 5-dimethylphenylboronic acid.
Safety Information:
When handling 4-bromo-2, 5-dimethylphenylboronic acid, the following safety precautions should be taken:
1. Avoid direct contact with skin and eyes, because it may cause irritation to skin and eyes.
2. use should wear appropriate personal protective equipment, such as gloves and protective glasses.
3. in the process of operation and storage should pay attention to fire prevention and avoid smoke and dust.
4. Storage should be placed in a closed container, away from fire and oxidant.
Last Update:2024-04-10 22:29:15